Destroy Creatures Combos

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Icy Manipulator + Royal Assassin: Tap Icy Manipulator to tap target creature, then use Royal Assassin’s ability to destroy the tapped creature.

Royal Assassin - {T}: Destroy target tapped creature. — Royal Assassin

Painter’s Servant + Grindstone: Use Painter’s Servant to make all cards in all libraries the same color, then use Grindstone to mill all opponents’ libraries until a nonland card with the chosen color is found and put it into their graveyard, repeating until all opponents have no cards left in their library.

Painter's Servant - As Painter's Servant enters the battlefield — Painter’s Servant

Blasphemous Act + Boros Reckoner: Use Blasphemous Act to deal 13 damage to all creatures, then use Boros Reckoner’s ability to redirect the damage to an opponent, potentially dealing lethal damage to all opponents.

Blasphemous Act - This spell costs {1} less to cast for each creature on the battlefield. — Blasphemous Act

Boros Reckoner - Whenever Boros Reckoner is dealt damage — Boros Reckoner

Kederekt Leviathan + Necromancy: Necromancy is an enchantment that allows you to bring a creature card from any graveyard onto the battlefield under your control. Kederekt Leviathan is a creature with an ability that triggers when it enters the battlefield or is sacrificed, forcing all players to return all non-land permanents to their owner’s hand. By bringing Kederekt Leviathan back with Necromancy, you can trigger its ability and force your opponent to return all of their creatures to their hand, while keeping your own creature on the battlefield.

Kederekt Leviathan - When Kederekt Leviathan enters the battlefield — Kederekt Leviathan

Necromancy - You may cast Necromancy as though it had flash. If you cast it any time a sorcery couldn't have been cast — Necromancy

Blasphemous Act + Repercussion: Blasphemous Act is a sorcery that deals 13 damage to all creatures. Repercussion is an enchantment that causes each time a creature is dealt damage, Repercussion deals that much damage to the creature’s controller. By playing Blasphemous Act and then Repercussion, you can deal a massive amount of damage to all of your opponent’s creatures and potentially even kill them if they have low enough life total.

Repercussion - Whenever a creature is dealt damage — Repercussion

Pestilence + Personal Sanctuary: Use Pestilence to deal 1 damage to all creatures and players, but with Personal Sanctuary, you won’t take any damage, effectively destroying all creatures.

Massacre Wurm - When Massacre Wurm enters the battlefield — Massacre Wurm

Damnation - Destroy all creatures. They can't be regenerated. — Damnation

Supreme Verdict + Teferi, Time Raveler: Supreme Verdict is a white sorcery that destroys all creatures. Teferi, Time Raveler is a planeswalker that lets you cast sorcery spells at instant speed and prevents your opponent from casting spells at instant speed. By playing Teferi first, you can cast Supreme Verdict at instant speed, wiping out your opponent’s creatures before they can do anything about it.

Supreme Verdict - This spell can't be countered. — Supreme Verdict

Pestilence + Circle of Protection: Black: Pestilence is a black enchantment that lets you pay X life to deal X damage to each creature and player. Circle of Protection: Black is an enchantment that prevents all damage from black sources for every 1 mana you tap into it.