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Life Damage Combos

Blasphemous Act + Boros Reckoner: Use Blasphemous Act to deal 13 damage to all creatures, then use Boros Reckoner’s ability to redirect the damage to an opponent, potentially dealing lethal damage to all opponents.

Blasphemous Act - This spell costs {1} less to cast for each creature on the battlefield. — Blasphemous Act

Boros Reckoner - Whenever Boros Reckoner is dealt damage — Boros Reckoner

Exquisite Blood + Sanguine Bond: Whenever you gain life with Exquisite Blood, Sanguine Bond triggers and your opponent loses life equal to the amount of life you gained. With both cards in play, the combo can be used to drain your opponent’s life total to zero.

Exquisite Blood - Whenever an opponent loses life — Exquisite Blood

Massacre Wurm + Damnation: Massacre Wurm gives -2/-2 to all creatures your opponent controls, and also deals 2 damage to your opponent each time a creature dies. Cast Damnation to destroy all creatures, triggering Massacre Wurm’s ability for even more damage to your opponent.